The structural characterization of proteins is typically performed in labs that have spectroscopy-based biophysical tools; in moving to techniques that can provide more granularity, a different set of skills is needed. Biophysical Mass Spectrometry provides a current and comprehensive assessment of the use of mass spectrometry in higher order structure characterization of proteins, with an emphasis on monoclonal antibodies as the predominant platform for biopharma. It aims to demonstrate how new and established techniques can be integrated. The book provides a reference to those wishing to pursue the adoption of new methods in the laboratory-based structural characterization of proteins.

Reviews current structural mass spectrometry techniques for use in the biopharmaceutical industry

Highlights new methodologies and focusses on integrating structural techniques

Gives in-depth reference information for those starting a lab devoted to the structural characterization of proteins

Provides sufficient detail for bench scientists to develop and implement structural mass spectrometry methods

Demonstrates how new and established techniques can be integrated